PISA — mitral regurgitation

Effective regurgitant orifice area, regurgitant volume and fraction for mitral regurgitation from the proximal isovelocity surface area.

Shared values — enter once, reused everywhere

Height

Weight

Heart rate

bpm

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PISA radius

Aliasing velocity

Peak MR velocity

MR VTI

EROA = 0.50 cm²

Severe range (EROA ≥ 0.40) · regurgitant volume 60 mL

Worked steps

PISA flow rate
Q = 2π r² × V_aliasing = 2π × 1.00² × 40 = 251 mL/s
Effective regurgitant orifice area
EROA = Q ÷ PkV_MR = 251 ÷ 500 = 0.50 cm²
Regurgitant volume
RVol = EROA × VTI_MR = 0.50 × 120.0 = 60 mL

Reference: ASE/EACVI recommendations on native valvular regurgitation (2017). EROA ≥ 0.40 cm² / RVol ≥ 60 mL indicates severe primary MR; thresholds differ for secondary MR.

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